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Literature summary extracted from

  • Takahashi, S.; Kuzuyama, T.; Watanabe, H.; Seto, H.
    A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis (1998), Proc. Natl. Acad. Sci. USA, 95, 9879-9884.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.267 overexpression in Escherichia coli Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.267 Cu2+
-
 Escherichia coli
1.1.1.267 EDTA
-
 Escherichia coli
1.1.1.267 Fe2+
-
 Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.267 Co2+ required for activity Escherichia coli
1.1.1.267 Mg2+ required for activity Escherichia coli
1.1.1.267 Mn2+ required for activity Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.267 42000
-
 4 * 42000, SDS-PAGE Escherichia coli
1.1.1.267 150000
-
 gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.267 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ Escherichia coli
-
 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.267 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.267 of recombinant protein Escherichia coli

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.267 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ mechanism Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.267 1-deoxy-D-xylulose 5-phosphate + NADPH + H+
-
 Escherichia coli 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
 ir

Subunits

EC Number Subunits Comment Organism
1.1.1.267 tetramer 4 * 42000, SDS-PAGE Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.267 7.5 8
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.267 NADP+
-
 Escherichia coli